Previously, PR has been reported in temporal association with various viral inoculations. 2021;35(8):e489e491. Though there's no single-known cause, it may be brought on by a drug interaction, or the reactivation of herpes simplex virus 6 or 7. National Library of Medicine It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. Human herpesvirus-6, -7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. Clipboard, Search History, and several other advanced features are temporarily unavailable. As vaccine reactogenicity reports continue to surface, dermatologists and other health care providers should understand the landscape of the latest cutaneous reactions to guide and address patients' concerns. -. official website and that any information you provide is encrypted Some patients may have a cold before the rash. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. Medicine (Baltimore). 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A If you have a very itchy rash, your healthcare provider may prescribe the following to help relieve your symptoms: There are several over-the-counter products or home remedies that can help stop your rash from itching. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. An official website of the United States government. Among patients who received inactivated vaccines, another case of PR-like eruption was reported four days after the first dose of CoronaVac (SinoVac) (1). Clin Dermatol. Skin Reactions After COVID-19 Vaccination Have Six Patterns - Medscape How quickly did it come on, and did my boyfriend also have it? This patch is the herald or mother patch. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Pityriasis rosea. Parakeratosis with minimal acanthosis, MeSH These strains of the herpes virus arent related to the strains that cause cold sores or genital herpes. Int J Infect Dis. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get more info about other skin conditions: The Ultimate Guide to Skin Conditions for Black & Brown Folks, I Thought I Just Had Dry Skin, But It Was Actually Perioral Dermatitis, Everything You Should Know About Hidradenitis Suppurativa. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Clinical manifestations and histopathologic findings of reported patients with pityriasis-rosea like eruptions following COVID-19 vaccination. 2022 by the American Academy of Dermatology, Inc. Pityriasis rosea commonly affects the skin on your trunk, arms or legs. doi: 10.1111/jdv.17342. "Sometimes it can spread to what we called the proximal extremities, meaning the parts that are closer to the trunk, so the shoulders, upper arms, [and] the thighs," she says. In some cases, central hyperpigmentation was identified. Advertising on our site helps support our mission. Atypical pityriasis rosea associated with mRNA COVID-19 vaccine. The transformation will take your breath away. government site. See this image and copyright information in PMC. doi: 10.1111/jdv.17498. What at-home treatments do you recommend? In: Jameson J, Fauci AS, Kasper DL, et al., eds. PMC 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. Coronavirus: Five skin conditions linked to COVID-19 after - 9News Disseminated erythematous-papulosquamous lesions, with right. The site is secure. A virus may cause pityriasis rosea, but experts aren't sure. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. Unable to load your collection due to an error, Unable to load your delegates due to an error. You also wont have permanent scarring or other damage to your skin. -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. sharing sensitive information, make sure youre on a federal National Library of Medicine The Moderna and Pfizer-BioNTech COVID-19 vaccines are the first two COVID-19 vaccines authorized by the Food and Drug Administration for emergency use and already have been given to millions of Americans. Patient concerns: Epub 2022 Jun 19. Theyre both papulosquoamous (pap-you-lo-skway-miss) disorders, which is a term used to characterize skin disorders according to the presence of raised, discolored, scaly patches of skin. government site. 2022 Oct;123:58-69. doi: 10.1016/j.ijid.2022.06.037. The .gov means its official. (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). PMC Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). Akdas E, Ilter N, Ogut B, Erdem O. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. Vaccination is one of the cornerstones in the efforts towards ending the coronavirus disease 2019 (COVID-19) pandemic. Numerous scattered erythematous, Pityriasis rosea. You may be more likely to develop it if youre: In some cases, people with pityriasis rosea report that they had significant or long-term stress before developing a rash. Could covid-19 infection cause pityriasis rosea why? HHS Vulnerability Disclosure, Help JAAD Int. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same . Appointments 216.444.5725 Appointments & Locations Request an Appointment However, a fungus causes ringworm. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage lines, most appreciable on the upper portion of the chest. National Library of Medicine Disclaimer. Treatment was initiated with systemic corticosteroid therapy - hydrocortisone hemisuccinate 200 mg/day for 7 days, and loratadine 10 mg 2 times a day. doi: 10.1111/ajd.13504. (2019) 34:185764. "Other treatments including phototherapy or oral medications can be considered for extensive or persistent cases, [and] some small case studies support the use of oral antivirals like acyclovir or oral anti-inflammatory antibiotics erythromycin," King explains. Pityriasis Rosea as a Possible Complication of Vaccination Against COVID-19. Cutaneous Eruptions in the Course of COVID-19 Among Geriatric Patients in a Nursing Home in Poland. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. Birlutiu V, Dobritoiu ES, Lupu CD, Herteliu C, Birlutiu RM, Dragomirescu D, Vorovenci A. This site needs JavaScript to work properly. Moreover, COVID-19 may solely induce human herpesvirus reactivation through the immunomodulatory ability of SARS-CoV-2 to reactivate latent viruses (8, 9). Apply a moisturizer, calamine lotion or a nonprescription . doi: 10.1016/j.jdcr.2018.04.002, 12. Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, Sendagorta-Cuds E, Feito-Rodrguez M, Nuo-Gonzlez A, et al. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. F. Drago, G. Ciccarese, A. Parodi J Am Acad Dermatol. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Pityriasis Rosea Induced by COVID-19 Vaccination - PubMed This rash is thought to be caused by a virus. The patients/participants provided their written informed consent to participate in this study. It is usually seen in children, adolescents, and young adults. User Agreement and Privacy Policy and Cookie Statement and While home remedies are safe for most people, its a good idea to check with your healthcare provider before trying some of the following options. (2006) 12:1. doi: 10.5070/D380D8301D, 11. How long will it take my body to clear the rash? Br J Dermatol. However, pityriasis rosea can look similar to other skin conditions, including: If theres any doubt, your healthcare provider may perform the following tests: In most cases, pityriasis rosea goes away without any treatment in six to eight weeks. Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Pityriasis rosealike rashes have been described after H1N1 influenza, HPV, diphtheria, poliomyelitis, smallpox, pneumococcal, hepatitis B and BCG vaccinations. A woman. Parakeratosis with minimal acanthosis and spongiosis of the epidermis. Unable to load your collection due to an error, Unable to load your delegates due to an error. These patches are smaller than the herald patch they range from 1 to 2 cm and are often called daughter patches. Please enable it to take advantage of the complete set of features! 2021;35(8):e489e491. Marcantonio-Santa Cruz OY, Vidal-Navarro A, Pesqu D, Gimnez-Arnau AM, Pujol RM, Martin-Ezquerra G. J Eur Acad Dermatol Venereol. 2021 Jul;85(1):46-55. doi: 10.1016/j.jaad.2021.03.092. Herzum A, Trave I, D'Agostino F, Burlando M, Cozzani E, Parodi A. Clin Exp Vaccine Res. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. Pityriasis rosea usually resolves on its own without treatment in most cases, King says, but topical corticosteroids can be used for itchy control if necessary, which is what I used. In: Knoop KJ, Stack LB, Storrow AB, et al., eds. Your symptoms dont improve after treatment. These types cannot cause cold sores or genital herpes. 2022 May;11(2):222-225. doi: 10.7774/cevr.2022.11.2.222. Unable to load your collection due to an error, Unable to load your delegates due to an error. Sriphojanart T, Khunkhet S, Suchonwanit P. A retrospective comparative study of the efficacy and safety of two regimens of diphenylcyclopropenone in the treatment of recalcitrant alopecia areata. Some treatments can alleviate related symptoms, including itching. 2023 Feb 9;11(2):397. doi: 10.3390/vaccines11020397. Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . All rights reserved. Bookshelf The cause of pityriasis rosea is not known, but it is commonly believed to be caused by a virus or bacteria. When to test for COVID-19 using real-time reverse transcriptase polymerase chain reaction: a systematic review. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection (2021) 60:11501. Characterization of the inflammatory cell infiltrate in herald patches and fully developed eruptions of pityriasis rosea. 8600 Rockville Pike Pityriasis rosea often occurs this way, but not always. Pityriasis rosea: An update on etiopathogenesis and management of difficult aspects. Table 1 summarizes all reported cases of PR-like eruption following COVID-19 vaccination. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. Although the exact pathogenesis of PR remains unknown, the endogenous systemic reactivation of HHV (i.e., type 6 and 7) in the skin has been implicated as a precipitating factor. 2022 Sep-Oct;40(5):586-590. doi: 10.1016/j.clindermatol.2022.01.002. Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. Human herpesvirus6, 7, and EpsteinBarr virus reactivation in pityriasis rosea during COVID19. An official website of the United States government. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. Epub 2022 Jun 26. (Within two days, and still no.) doi: 10.7759/cureus.27108. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Pityriasis Rosea (Christmas Tree Rash): Causes & Treatment eCollection 2022. J Med Virol 2021; 93: 1850-1851. COVID-19; SARS-CoV-2; pityriasis rosea; vaccination. 1. At first, I thought it was a mosquito bite. From grooming sets to self-care gadgets, we've got them covered. Last reviewed by a Cleveland Clinic medical professional on 06/17/2022. COVID-19; Vaccination; pityriasis rosea. J Eur Acad Dermatol Venereol 2016; 30: 544545. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Drago F, Ciccarese G, Rebora A, Parodi A. 2022 Oct 4;15:2117-2127. doi: 10.2147/CCID.S371630. J Med Virol. A spectrum of cutaneous reactions to SARs-CoV-2 (COVID-19) vaccines have been reported in the literature. doi: 10.1016/j.jaad.2020.04.094, 8. It was described as "clinically reminiscent" of pityriasis rosea by the authors, from the divisions of dermatology and venereology, pathology, intensive care, and the virology laboratory, of the Hpital Cochin, Paris. Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. Epub 2022 Jun 21. 2022 Dec;9:127. doi: 10.1016/j.jdin.2022.03.018. The https:// ensures that you are connecting to the and transmitted securely. -, Drago F, Ciccarese G, Javor S, Parodi A. Vaccineinduced pityriasis rosea and pityriasis rosealike eruptions: a review of the literature. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). These skin conditions can include, among other things, hives, measles-like rashes and a full body rash similar to pityriasis rosea. Some rare cases can take up to three months. Most of the rare, severe allergic reactions to these vaccines have occurred in people with a history of allergies. Pityriasis rosea-like eruption presenting as multiple discrete erythematous oval patches and plaques on the back (A) lower abdomen, and bilateral upper thighs (B); lesions distributed along cleavage lines without prominent scales (C). Suchonwanit P, Rojhirunsakool S, Khunkhet S. A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. The .gov means its official. Foods that have anti-inflammatory properties include: Foods that may increase inflammation include: There isnt any way to prevent pityriasis rosea. Epub 2021 Aug 7. (2021) 85:4655. Please enable it to take advantage of the complete set of features! sharing sensitive information, make sure youre on a federal 2022 Aug;87(2):295. doi: 10.1016/j.jaad.2022.06.036. Herald patch of pityriasis rosea. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). Pityriasis rosea isnt a sexually transmitted disease or infection (STD or STI). doi: 10.1159/000517971. Clinical aspect of the lesions after 7 days of treatment. Ciccarese G, Parodi A, Drago F. SARS-CoV-2 as possible inducer of viral reactivations. Pityriasis rosea after mRNA COVID-19 vaccination - PubMed National Library of Medicine Lessons: Careers. As King notes, there have been some reported cases of pityriasis rosea occurring in patients after receiving certain vaccines, like the flu shot. -, Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. A case of Pityriasis rosea is presented in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. (2016) 30:5445. Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. The patches may itch. Epub 2022 May 3. Pityriasis Rosea Induced by COVID preview & related info | Mendeley At home, she underwent systemic treatment with antihistamines and topical medication with dermatocorticosteroids. doi: 10.1111/jdv.12942, 13. Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Int J Dermatol. (b) haematoxylineosin, original magnification 20. Pityriasis rosea is a common condition that causes discolored patches on your skin. Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. Hum Vaccin Immunother. We present two cases of COVID-19 vaccine-induced pityriasis rosea. Disclaimer. -. Vaccinations have been identified to rarely cause several cutaneous reactions. Epub 2021 Apr 7. J Formos Med Assoc. (Unfortunately, I scratched my rash until it bled, so my hyperpigmentation may linger.). government site. Pityriasis rosea: Diagnosis and treatment - American Academy of Dermatology In addition to a corticosteroid cream, New York City-based dermatologist Macrene Alexiades recommends keeping showers short and lukewarm, as "water, sweat, and soap reportedly irritate and inflame the lesions. Cazzato G, Ambrogio F, Pisani MC, Colagrande A, Arezzo F, Cascardi E, Dellino M, Macorano E, Trilli I, Parente P, Lettini T, Romita P, Marzullo A, Ingravallo G, Foti C. Vaccines (Basel). Refined carbohydrates, such as sugar, pastries and white bread. JAAD Int. The papillary dermis shows melanin incontinence, perivascular lymphocytic infiltrate and rare scattered extravasated red blood cells. Get many smaller patches or bumps on your skin. (2021) 35:e4913. The site is secure. Federal government websites often end in .gov or .mil. They were found on hands and feet, showing up as red or purple spots caused by bleeding under the skin. Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. Histopathological Patterns of Cutaneous Adverse Reaction to Anti-SARS-CoV-2 Vaccines: The Integrative Role of Skin Biopsy. Federal government websites often end in .gov or .mil. doi: 10.1111/jdv.17342, 5. Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy Reaction in Thai Population: A 20-Year Retrospective Study. Pityriasis rosea is also known as Christmas tree rash. FOIA You may develop a raised, discolored, circular or oval-shaped patch that ranges from 1 to 6 centimeters (cm). 2021 Aug;185(2):e34. 2022 Aug 11;9(8):43. doi: 10.3390/medicines9080043. Of the 30 cases found, none experienced severe adverse effects and the rash resolved in an average of 5.6 weeks. 2022 Jul 21;14(7):e27108. The authors suggest more research is necessary. Even though it is benign, it can cause substantial. See this image and copyright information in PMC. Inverse pityriasis rosea secondary to COVID-19 vaccination. The herald patch is the telltale sign that your rash could be PR, but there are other common (though not universal) symptoms as well. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. . doi: 10.7759/cureus.22414. Physicians should be aware that pityriasis rosea is a rare side-effect of COVID-19 vaccination.Pityriasis rosea is self-limiting and no medical treatment is usually required. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. 8600 Rockville Pike Epub 2022 Oct 17. Epub 2021 May 10. J Investig Dermatol 2005;124:123440. You may be at risk of developing an allergic reaction on your skin. In approximately 50% of people with pityriasis rosea, the patches itch. The average time between vaccination and rash onset is 10 days, and most patients experience pruritus (70%). Pityriasis Lichenoides - Dermatologic Disorders - Merck Manuals This reaction is self-limited and resolves in an average of 5.6 weeks. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. Before Australas J Dermatol. Some people develop a few large patches on their skin. 2022 May;121(5):1003-1007. doi: 10.1016/j.jfma.2021.12.028. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature JAAD Int. Lasers Med Sci. doi: 10.1111/j.0022-202X.2005.23719.x. But some patients also are developing delayed skin reactions on. Its important to pay attention to your skin. Following the national COVID-19 vaccination guidelines, she received a shot of ChAdOx1 nCoV-19 (AZD1222) vaccine before the therapy. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Careers. Int J Dermatol. Would you like email updates of new search results? and transmitted securely. Flares of other types of skin conditions [like psoriasis] sometimes have been described as well," says Lam. Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. (2015) 2015:253154. doi: 10.1155/2015/253154, 14. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of Cond Nast. eCollection 2022. Epub 2021 Nov 2. -, Broccolo F., Drago F., Careddu A.M., et al. Please enable it to take advantage of the complete set of features! Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. HHS Vulnerability Disclosure, Help Dermoscopy of the lesions showing peripheral collarette scaling, blood Pityriasis rosea and pityriasis rosea-like eruptions after COVID-19 vaccines. Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin. It's also what's known as a self-limiting rash, Hartman says, in that it can resolve itself on its own without treatment in about six to eight weeks. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. 2022 Aug;20(8):1123-1124. doi: 10.1111/ddg.14784. Children often get infected when someone sneezes or kisses them. Factors affecting the severity of central centrifugal cicatricial alopecia. The condition is more prevalent in spring and fall. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. eCollection 2022. Oueijan RI, Hill OR, Ahiawodzi PD, Fasinu PS, Thompson DK. Lastly, Hartman says PR can present differently in patients with darker skin: "The characteristic erythematous plaques may appear more hyperpigmented or violaceous in darker skin types. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. HHS Vulnerability Disclosure, Help Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. If you have pityriasis rosea, you dont have to avoid any foods or drinks. doi: 10.1111/jdv.17301. Department of Dermatology, Graduate School of Medicine, Kyusyu University, Japan. Pityriasis rosea-like Covid-arm Erythema multiforme Erythroderma Psoriasis Others Grover-like eruptions Herpes simplex reactivation: 24 1 17 4 2 2 1 1 20 15 9 5 2 1 1 1 3 3: 21.5 0.9 15 3.5 1.8 1.8 0.9 0.9 The .gov means its official. Pityriasis rosea, COVID19 and vaccination: new keys to understand an Med. Epub 2022 Jan 5. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). See this image and copyright information in PMC. However, several adverse effects of COVID-19 vaccination have been identified. I put on some hydrocortisone and went to sleep, then woke up with another mark on my side, a couple inches below my armpit. And the itch usually only lasts for a few days mine finally let up around day seven but the rash can leave behind dark marks that eventually resolve on their own, Lam says. Among the common cutaneous manifestations of COVID-19 (e.g., morbilliform eruptions, chilblains, and varicella-like vesicles), PR and PR-like eruptions have rarely been described (6, 7). Some studies have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins on endothelial cells and lymphocytes from PR-like lesions, consistent with direct viral invasion (3, 4).