Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) 1998 Feb;25(1):65-8. Applies only to oral form of both agents. Copyright 1993-2021 In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Use Caution/Monitor. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Applies only to oral form of both agents. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Interaction only with oral iron administration. Either increases effects of the other by pharmacodynamic synergism. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. 1000 mg. 20 MINUTES. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Use Caution/Monitor. 2010;18(3). Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. 1. Applies only to oral form of both agents. MISSED DOSE: It is important to get each dose of this medication as scheduled. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Burns DL, Mascioli EA, Bistrian BR. PDF Iron dosing and administration in adults backgrounder Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. PDF Highlights of Prescribing Information Contraindications- Venofer Use Caution/Monitor. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). STORAGE: Consult the product instructions and your pharmacist for storage details. Parenteral iron dose - UpToDate Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Do not double the dose to catch up. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. The iron formulation choice remains for the clinician to make. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. . Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Use Caution/Monitor. Individual plans may vary IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Controlled studies in pregnant women show no evidence of fetal risk. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Venofer treatment may be repeated if iron deficiency reoccurs. Venofer may cause clinically significant hypotension. A healthcare provider will give you this injection. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Minor/Significance Unknown. This site contains information for licensed healthcare professionals in the United States. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Information last revised December 2022. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. . Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Use Caution/Monitor. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Nutrition. Consult your doctor before breast-feeding. 10th ed. Fulminant symptoms include confusion, sensation of passing out, paleness. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Applies only to oral form of both agents. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Minor/Significance Unknown. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Dosing: (a) Divide calculated total cumulate dose . Minor/Significance Unknown. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Minor/Significance Unknown. Applies only to oral form of both agents. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Applies only to oral form of both agents. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Modify Therapy/Monitor Closely. The recipient will receive more details and instructions to access this offer. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Assure stable intravenous access to avoid extravasation. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Schrier SL, Mentzer WC, Landaw SA. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. Baloxavir may bind to polyvalent cations resulting in decreased absorption. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . The dosage of Venofer is expressed in mg of elemental iron. Creating an account is free and takes less than 1 minute. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Applies only to oral form of both agents. provider for the most current information. Treatment of anemia due to iron deficiency. Applies only to oral form of both agents. Dose. Use Caution/Monitor. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Anemias. The dosage of iron sucrose is expressed in mg of elemental iron. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Applies only to oral form of both agents. Applies only to oral form of both agents. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. elemental iron (mg/ml) in the product being used: Where C= If you log out, you will be required to enter your username and password the next time you visit. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Use Caution/Monitor. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. It is unlikely . Iron sucrose | Drugs | BNF | NICE Applies only to oral form of both agents. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Iron sucrose: 20 mg/mL. LBW = Lean body weight in kg. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. 1990 Feb;24(2):162-6. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Canada residents can call a provincial poison control center. 1995 Mar-Apr;11(2):163-8. Deferoxamine chelates iron. Avoid or Use Alternate Drug. Do not administer Venofer to patients with evidence of iron overload. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. The above information is provided for general Properly discard this product when it is expired or no longer needed. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Use Caution/Monitor. Ferric gluconate: 12.5 mg/mL. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Applies only to oral form of both agents. PDF Treatment Guideline - Gloucestershire Royal Hospital PDF IRON PRODUCT CHOICE AND DOSE CALCULATION - Blood Deferasirox chelates iron. 1974 Jun;31(6):592-5. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Use Caution/Monitor. No data are available regarding overdosage of Venofer in humans. Applies only to oral form of both agents. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Each mL contains 20 mg of elemental . Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This website is intended for use by US healthcare professionals only. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. 1996 Aug;11(4):139-46. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. (See also Notes section. Diagnosis and management of iron deficiency anaemia: a clinical update. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Applies only to oral form of both agents. ]Venofer treatment may be repeated if iron deficiency reoccurs. Use Caution/Monitor. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Iron Sucrose (Ferogen): Indications, Dosage, Administration - Medcrine Avoid or Use Alternate Drug. iron sucrose, captopril. Use Caution/Monitor. Kidney Int. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Applies only to oral form of both agents. Iron sucrose: 20 mg/mL. Applies only to oral form of both agents. Most Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Venofer treatment may be repeated if necessary. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. 1 ,*. The dosage of Venofer is expressed in mg of elemental iron. Schweiz Med Wochenschr; 100(7):301-3. Modify Therapy/Monitor Closely. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Separate by at least 4 hours. Avoid or Use Alternate Drug. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Copyright(c) 2023 First Databank, Inc. Separate by at least 4 hours. commonly, these are "preferred" (on formulary) brand drugs. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Applies only to oral form of both agents. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Objective. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration 2012;2(4):288-335. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Applies only to oral form of both agents. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Venofer (iron sucrose) dosing, indications, interactions, adverse ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. 2000 Jan;22(1):39-43. Recommended dosing and infusion rates for PI. Minor/Significance Unknown. This drug is available at the lowest co-pay. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Keep all medical and lab appointments. ONE DOSE. Ferric carboxymaltose (Ferinject) for iron-deficiency anaemia Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Use Caution/Monitor. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. For liquid medications, also enter the value of the Medicine Concentration and choose . 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update.
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